R4第6回医科研セミナークラブ

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At the initial step of carcinogenesis, transformation occurs in a single
cell within an epithelial sheet. However, it remains elusive what
happens at the boundary between normal and the newly emerging
transformed cells. Using newly established cell culture and mouse
model systems, we have shown that various phenomena can occur at
the interface between normal and transformed epithelial cells.
For example, when Ras-transformed cells are surrounded by normal
epithelial cells, the transformed cells are often eliminated from the
apical surface of the epithelial monolayer. This phenomenon is not
observed when transformed cells alone are present, suggesting that
the presence of surrounding normal cells affects the signaling
pathways and fate of transformed cells. Furthermore, we have
demonstrated that normal epithelial cells can recognize and actively
eliminate various types of transformed cells and named this process
EDAC (Epithelial Defense Against Cancer).
In this webinar talk, I will present our findings on cell competition
and discuss how this study can lead to the establishment of novel
types of cancer preventive treatment.

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